2023

1.Rigg, E., Wang, J., Xue, Z., Lunavat, T. R., Liu, G., Hoang, T., Parajuli, H., Han, M., Bjerkvig, R., Nazarov, P. V., Nicot, N., Kreis, S., Margue, C., Nomigni, M. T., Utikal, J., Miletic, H., Sundstrøm, T., Ystaas, L. A. R., Li, X., & Thorsen, F. (2023). Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes.Journal of extracellular vesicles,12(10), e12363.https://doi.org/10.1002/jev2.12363

2. Li, Z., Qi, Y., Sun, L., Li, Z., Chen, S., Zhang, Y., Ma, Y., Han, J., Wang, Z., Zhang, Y., Geng, H., Huang, B., Wang, J., Li, G., Li, X., Wu, S., & Ni, S. (2023). Three-dimensional nanofibrous sponges with aligned architecture and controlled hierarchy regulate neural stem cell fate for spinal cord regeneration.Theranostics,13(14), 4762–4780.https://doi.org/10.7150/thno.87288

3. Li, Y., Liu, X., Zhao, F., Zhao, Z., Li, X., Wang, J., Huang, B., & Chen, A. (2024). Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma.CNS neuroscience & therapeutics,30(2), e14366.https://doi.org/10.1111/cns.14366

4. Wang, J., Chen, A., Xue, Z., Liu, J., He, Y., Liu, G., Zhao, Z., Li, W., Zhang, Q., Chen, A., Wang, J., Li, X., Wang, X., & Huang, B. (2023). BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma.Cell death & disease,14(9), 585.https://doi.org/10.1038/s41419-023-06112-4

5. Che, T., Wang, X., Zhao, K., Zhao, Y., Zeng, D., Li, Q., Zheng, Y., Yang, N., Wang, J., & Li, S. (2023). AMNet: Adaptive multi-level network for deformable registration of 3D brain MR images.Medical image analysis,85, 102740.https://doi.org/10.1016/j.media.2023.102740

6. Zhao, W., Wu, Y., Wang, S., Zhao, F., Liu, W., Xue, Z., Zhang, L., Wang, J., Han, M., Li, X., & Huang, B. (2024). HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.CNS neuroscience & therapeutics,30(2), e14605. https://doi.org/10.1111/cns.14605

2022

1. Joseph, J. V., Magaut, C. R., Storevik, S., Geraldo, L. H., Mathivet, T., Latif, M. A., Rudewicz, J., Guyon, J., Gambaretti, M., Haukas, F., Trones, A., Rømo Ystaas, L. A., Hossain, J. A., Ninzima, S., Cuvellier, S., Zhou, W., Tomar, T., Klink, B., Rane, L., Irving, B. K., … Miletic, H. (2022). TGF-β promotes microtube formation in glioblastoma through thrombospondin 1.Neuro-oncology,24(4), 541–553.https://doi.org/10.1093/neuonc/noab212.

2. Cheng, B., Ding, K., Chen, P., Ji, J., Luo, T., Guo, X., Qiu, W., Ma, C., Meng, X., Wang, J., Yu, J., & Liu, Y. (2022). Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer.Cancer communications (London, England),42(1), 17–36.https://doi.org/10.1002/cac2.12244.

3. Zhang, S., Zhao, S., Qi, Y., Li, B., Wang, H., Pan, Z., Xue, H., Jin, C., Qiu, W., Chen, Z., Guo, Q., Fan, Y., Xu, J., Gao, Z., Wang, S., Guo, X., Deng, L., Ni, S., Xue, F., Wang, J., … Li, G. (2022). SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner.Molecular therapy. Nucleic acids,27, 699–717.https://doi.org/10.1016/j.omtn.2021.12.035.

4. Qi, Y., Jin, C., Qiu, W., Zhao, R., Wang, S., Li, B., Zhang, Z., Guo, Q., Zhang, S., Gao, Z., Zhao, S., Pan, Z., Fan, Y., Chen, Z., Wang, H., Xu, J., Deng, L., Ni, S., Wang, J., Xue, H., … Li, G. (2022). The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs.Cell death & disease,13(5), 426.https://doi.org/10.1038/s41419-022-04872-z.

5. Wang, X., Han, M., Wang, S., Sun, Y., Zhao, W., Xue, Z., Liang, X., Huang, B., Li, G., Chen, A., Li, X., & Wang, J. (2022). Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.Theranostics,12(12), 5451–5469.https://doi.org/10.7150/thno.72248.

6. Yang, X., Zhang, Y., Xue, Z., Hu, Y., Zhou, W., Xue, Z., Liu, X., Liu, G., Li, W., Liu, X., Li, X., Han, M., & Wang, J. (2022). TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein.Journal of experimental & clinical cancer research : CR,41(1), 336.https://doi.org/10.1186/s13046-022-02534-8.

2021

1. Ji J, Ding K, Luo T, Zhang X, Chen A, Zhang D, Li G,Thorsen F,Huang B*,Li X*,Wang J*. TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα. Cell Death Differ. 2021 Jan;28(1):367-381. https://doi: 10.1038/s41418-020-00606-w.

2. Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., Zhao, F., Zhao, Z., Wang, J., Huang, B., Chen, A., Yao, Z., Han, M., Feng, Z., Hu, Y., Thorsen, F., Wang, J., & Li, X. (2021). Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines.Oncogene,40(8), 1425–1439.https://doi.org/10.1038/s41388-020-01622-3.

3.Qiu, W., Guo, X., Li, B., Wang, J., Qi, Y., Chen, Z., Zhao, R., Deng, L., Qian, M., Wang, S., Zhang, Z., Guo, Q., Zhang, S., Pan, Z., Zhao, S., Xue, H., & Li, G. (2021). Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells.Molecular therapy : the journal of the American Society of Gene Therapy,29(12), 3449–3464.https://doi.org/10.1016/j.ymthe.2021.06.023.

4. Han, M., & Rudewicz, J. (2021). New insights into the molecular genetics of recurrent malignant gliomas.Journal of molecular medicine (Berlin, Germany),99(2), 257–259.https://doi.org/10.1007/s00109-020-02021-7.

2020

1. Ji, J., Ding, K., Luo, T., Xu, R., Zhang, X., Huang, B., Chen, A., Zhang, D., Miletic, H., Bjerkvig, R., Thorsen, F., Wang, J., & Li, X. (2020). PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1.Oncogene,39(5), 1125–1139. https://doi.org/10.1038/s41388-019-1050-9.

2. Han, M. Z., Huang, B., Ni, S. L., Wang, J., Li, X. G., & Bjerkvig, R. (2020). A validated prognostic nomogram for patients with newly diagnosed lower-grade gliomas in a large-scale Asian cohort.Neuro-oncology,22(5), 729–731.https://doi.org/10.1093/neuonc/noaa027.

3. Kong Y, Feng ZC, Zhang YL, Liu XF, Ma Y, Zhao ZM, Huang B, Chen AJ, Zhang D,Thorsen F,Wang J,Yang N*,Li XG*. Identification of Immune-Related Genes Contributing to the Development of Glioblastoma Using Weighted Gene Co-expression Network Analysis. Front Immunol. 2020 Jul 16;11:1281. doi: 10.3389/fimmu.2020.01281.

4. Han M, Wang S, Fritah S, Wang X, Zhou W, Yang N, Ni S, Huang B, Chen A, Li G, Miletic H,Thorsen F,Bjerkvig R*, Li X*,Wang J*. Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling. Brain. 2020 Feb 1;143(2):512-530. doi: 10.1093/brain/awz406.

5. Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen A,Wang J*,Li X*,Thorsen F*. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. Am J Cancer Res 2020 Feb 1, 10(2)545-563.

2019

1. Han M, Wang S, Yang N, Wang X, Zhao W, Saed HS, Daubon T, Huang B, Chen A, Li G, Miletic H,Thorsen F,Bjerkvig R*,Li X*,Wang J*. Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma. EMBO Mol Med. 2020 Jan 9;12(1):e10924. doi: 10.15252/emmm.201910924. Epub 2019 Nov 28.

2. Feng Z, Zhou W, Wang J, Qi Q, Han M, Kong Y, Hu Y, Zhang Y, Chen A, Huang B, Chen A, Zhang D, Li W, Zhang Q,Bjerkvig R,Wang J*, Thorsen F*, Li X*. Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma. J Cell Mol Med. 2020 Mar;24(5):2847-2856. doi: 10.1111/jcmm.14840. Epub 2019 Nov 28.

3. Bernatz S, Ilina E, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C,Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. J Exp & Clin Cancer Res 2019 Oct 29;38(1):434. doi:10.1186/s13046-019-1427-1.

4. Aasen SN, Espedal H, Holte CF, Keunen O, Karlsen TV, Tenstad O, Maherally Z, Miletic H, Hoang T, Eikeland AV, Baghirov H, Olberg DE, Pilkington GJ, Sarkar G, Jenkins R, Sundstrom T,Bjerkvig R,Thorsen F. Improved drug delivery to experimental melanoma brain metastasis by peptide-mediated permeabiliztion of the blood-brain barrier. Mol Cancer Ther 2019 Aug 29. doi:10.1158/1535-7163.MCT-19-0160.

5. Aasen SN, Parajuli H, Hoang T, Feng Z, Stokke K,Wang J, Roy K,Bjerkvig R, Knappskog S,Thorsen F. Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors. Int J Mol Sci 20(17):4235, Aug 29, 2019. doi:10.3390/ijms20174235.

6. Sundstrom T, Prestegarden L, Azuaje F, Rosland GV, Varughese JK, Aasen SN, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Inghem ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M,Bjerkvig R*,Thorsen F*. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Comm 7:55, Apr 10, 2019.

2018

1. Johannessen TC, Hasan-Olive MM, Zhu H, Denisova O, Grudic A, Latif MA, Saed H, Varughese JK, Rosland GV, Yang N, Sundstrom T, Nordal A, Tronstad KJ,Wang J, Lund-Johansen M, Simonsen A, Janji B, Westermarck J,Bjerkvig R, Prestegarden L. Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. Int J Cancer. 2019 Apr 1;144(7):1735-1745. doi: 10.1002/ijc.31912. Epub 2018 Dec 11.

2. Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Jiang Z,Bjerkvig R, Prestegarden L,Thorsen F, Wang X,Li X*,Wang J*. Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. Autophagy. 2018;14(11):2007-2022. doi: 10.1080/15548627.2018.1501133. Epub 2018 Aug 17.

2017

1. Fack F, Tardito S, Hochart G, Oudin A, Zheng L, Fritah S, Golebiewska A, Nazarov PV, Bernard A, Hau AC, Keunen O, Leenders W, Lund-Johansen M, Stauber J, Gottlieb E,Bjerkvig R, Niclou SP. Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways. EMBO Mol Med. 2017 Dec;9(12):1681-1695. doi: 10.15252/emmm.201707729.

2. Obad N, Espedal H, Jirik R, Sakariassen PO, Brekke Rygh C, Lund-Johansen M, Taxt T, Niclou SP,Bjerkvig R, Keunen O. Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma. J Cereb Blood Flow Metab. 2018 Oct;38(10):1741-1753. doi: 10.1177/0271678X17714656. Epub 2017 Jun 19. PMID: 28627960; PMCID: PMC6168744.