Frits Alan Thorsen，1964年出生于挪威，现任挪威卑尔根大学讲席教授、生物医学系副主任、分子影像中心主任，是山东省“外专双百计划”外国专家，同时也是癌症转化研究团队的重点课题组癌症转移研究组的负责人。研究团队在针对脑转移瘤的发生发展和临床治疗等研究方向上取得了卓越的成绩，本人也被认为是脑转移瘤临床前研究的世界前沿顶尖专家之一。2008年与山东大学齐鲁医院开展了实质性的合作，目前是山东大学联合培养研究生海外导师。曾获挪威科研委员会、挪威癌症协会和欧洲委员会的系列重大资助。共培养硕士生33人，博士生10人，博士后3人，发表SCI论文60余篇。
教育经历
1989年，获特隆赫姆大学物理学硕士
1998年，获卑尔根大学细胞与分子生物学博士，主要研究方向为临床前癌症研究
职位成就
2004年，担任卑尔根大学生物医学系副教授
2010年，担任卑尔根大学生物医学系教授
2019年，担任山东大学客座教授
荣誉奖项
2011年，获挪威富布赖特基金会资助赴加州大学戴维斯分校访问教授
2014年，CRS杰出论文奖
研究成果
2010-2014年，作为卑尔根大学与卢森堡卫生研究院博士培养项目主要负责人，开发了新的动物多模成像技术来研究胶质瘤侵袭、血管生成、肿瘤代谢及治疗反应等特性，目前致力于利用多模成像技术进行恶性脑肿瘤的新治疗策略临床转化研究。
主持科研项目
2023-2026，Targeting crosstalk between tumor cells and the brain metastatic niche in melanoma brain metastasis，Partner
2022-2026，Norwegian Advanced Light Microscopy Network 2，Partner
2018-2020，Inhibiting Brain Metastasis by Modulating the Blood-Brain Barrier，Project Leader
2017-2021，Finding New Uses for Old Drugs in Clinical Treatment of Brain Metastases，Project Leader
2017-2022，Norwegian Molecular Imaging Infrastructure，Partner
2016-2019，Repurposing Drugs for Clinical Treatment of Brain Metastasis
主要学术著作
1. Rigg E, Wang J, Xue Z, Lunavat T, Liu G, Hoang T, Parajuli H, Han M, Bjerkvig R, Nazarov P, Nicot N, Kreis S, Margue CW, Nomigni MT, Utikal J, Miletic H, Sundstrøm T, Li X, Thorsen F. Inhibition of extracellular vesicle derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes. Journal of Extracellular Vesicles 2023, Oct; 12(10):e12363. doi: 10.1002/jev2.12363. [IF 17.337]
2. Spitzer D, Guérit S, Khel M, Pütz T, Zinke J, Jia X, Sommer K, Filipski K, Thorsen F, Freiman T, Harter P, Reiss Y, Liebner S, Di Tacchio M, Devraj K. A flow cytometry based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues. Nature Protocols 2023 May, 18(5):1510-1542. doi:10.1038/s41596-023-00805-y. [IF 14.8]
3. Mannsåker TA, Hoang T, Aasen SN, Bjørnstad OV, Parajuli H, Sundstrøm T, Thorsen F. Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways. International Journal of Molecular Sciences 2021 Nov 14, 22(22):12296. [IF 5.6]
4. Valiente M, Van Swearingen AED, Anders C, Bairoch A, Boire A, Bos P, Cittelly D, Erez N, Ferraro G, Fukumura D, Gril BM, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massagué J, Neman J, Sibson N, Steeg P, Thorsen F, Young L, Vareslija D, Vultur A, Weis-García F, Winkler F. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Research 2020 July 8. [IF 11.2]
5. Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen A, Wang J*, Li X*, Thorsen F*. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. American Journal of Cancer Research 2020 Feb 1, 10(2):545-563. [IF 5.3]
6. Sundstrøm T, Prestegarden L, Azuaje F, Røsland GV, Varughese JK, Aasen SN, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Inghem ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Bjerkvig R*, Thorsen F*. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathologica Communications 7:55, Apr 10, 2019. doi: 10.1186/s40478-019-0712-8. [IF 7.1]
7. Sundstrøm T, Espedal H, Harter P, Fasmer KE, Skaftnesmo KO, Horn S, Hodneland E, Mittelbronn M, Weide B, Beschorner R, Bendner B, Rygh CB, Lund-Johansen M, Bjerkvig R, Thorsen F. Melanoma brain metastasis is independent on LDHA expression. Neuro-Oncology 17:1374-1385, 2015. [IF 15.9]
8. Keunen O, Taxt T, Tonn JC, Grüner R, Lund-Johansen M, Pavlin T, Bjerkvig R, Niclou S, Thorsen F. Multimodal imaging of gliomas in the context of cellular and molecular therapies. Advanced Drug Delivery Research 76:98-115, 2014. [IF 16.1]
9. Thorsen F, Fite B, Mahakian L, Seo JW, Qin SP, Harrison V, Johnson S, Ingham E, Meade T, Caskey C, Sundstrøm T, Meade T, Harter PN, Skaftnesmo KO, Ferrara KW. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. Journal of Controlled Release 172:812-822, 2013. [IF 11.467]
10. Sundstrøm T, Daphu I, Wendelbo I, Hodneland E, Lundervoll A, Immervoll H, Skaftnesmo KO, Babic M, Jendelova P, Sykova E, Lund-Johansen M, Bjerkvig R, Thorsen F. Quantitative tracking of nanoparticle labeled melanoma cells improves the predictive power of an experimental brain metastasis model. Cancer Research 73(8):2445-2456, 2013. [IF 11.2]
